In pSS, HLA DRB1-0301 allele is strongly associated with the Interferon signature and with anti-SSA/anti-SSB production.11 Similarly, genetic predisposition to AIH in adults is associated with possession of DRB1*03, -04 alleles.12 These basic findings suggest that pSS, IgAN and AIH are attributable to common aetiopathogenesis. This evidence concerns the gene SSB and autoimmune hepatitis.