The following data were collected from each included article: age of cases, gender, date of COVID-19 infection, COVID-19 infection severity (based on the United States Centres for Disease Control and Prevention definition of severe outcomes of COVID-19 as hospitalisation, admission to the intensive care unit (ICU), intubation or mechanical ventilation, or death,13), date of the joint symptoms onset, C-reactive protein (CRP), rheumatoid factor (RF) and Anti-citrullinated protein antibodies (ACPA) positivity, treatment, and treatment outcomes. The gene discussed is CRP; the disease is COVID-19.