Hippocampal volumes differed significantly, with NC subjects > stable aMCI > progressive aMCI. Raw values not provided.Compared with NC subjects, progressive aMCI subjects had significantly greater atrophy rates in both right and left HP. Compared to stable aMCI subjects, progressive aMCI subjects had faster atrophy rate in right, but not left, HP.There were no APOE4 group effects on neuropsychological or MRI volumetric assessments. In MCI subjects, there was a significant correlation between the decline in memory scores and HP atrophy rates. This evidence concerns the gene APOE and Atrophy.