Good examples are a schweinfurthin derivative targeting OSBP and having a distinct antitumor effect in a glioblastoma xenograft model when combined with the previously used drug temozolomide (Jezequel et al., 2023), and orpinolide, a synthetic analog that disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP (Cigler et al., 2024). Here, OSBP is linked to glioblastoma.