FOXO3 and cardiac hypertrophy: A large number of studies have indicated thatFOXO3A plays an important role in cardiac hypertrophy [9,10,35] .FOXO3A may affect cardiac hypertrophy by regulating the phosphorylated glycogen synthase kinase-3β (p-GSK3β)/β-catenin/cyclin D1 signaling pathway, the ratio of p-FOXO3A toFOXO3A, and the nuclear level ofFOXO3A.