In tumor cells, PABPN1 exerts dual action on proliferation: it affects the progression of hepatoblastoma (HB) and clear cell renal cell carcinoma (ccRCC) by promoting cell proliferation [11,12], while inhibits the proliferation of human alveolar adenocarcinoma cell A549-tTA and bladder cancer (BC) cells [13,14]. Here, PABPN1 is linked to breast cancer.