Along with the identification of microbiome specific for CRC, pre-diagnostic protein markers such as serum carcinoembryonic antigen (CEA), basigin (CD147) and glycoprotein A33 (GPA33) have also been identified in accordance with the occurrence of CRC [25, 26], besides Actin Beta Like 2 (ACTBL2), Dipeptidase 1 (DPEP1), fibroblast growth factor 21 (FGF-21) and pancreatic prohormone (PPY) [27, -29]. Here, ACTBL2 is linked to colorectal carcinoma.