TNF and colorectal carcinoma: Resembling these information, a randomized double-blind placebo-controlled trial found that consuming the probiotic mixture of 30 × 1010 CFU Lactobacillus and Bifidobacteria for six months led to decrease in levels of cytokines such as TNF-α, IL-6, IL-10, IL-12, IL-17A, IL-17C and IL-22, whereas, there was no significant changes in IFN-γ levels in serum of CRC patients [62].