Similarly, in tumour cells, we observed upregulation of H3K27me3 modification on immune cell lineage marker PTPRC, as well as olfactory receptor family members (OR5M3, OR5M8, and OR13C4), and homeobox proteins (HOXB2, HOXA1, and HOXA4), which are associated with sensory perception and embryonic development, respectively (Figure 4D; Figure S3F).36, 37. The gene discussed is HOXB2; the disease is neoplasm.