Genes such as METTL160 and CRB2,61 known to be associated with poor prognosis, showed upregulated H3K27me3 modification in C1, while tumour suppressor genes ARHGAP962, 63 and TNFSF964 showed upregulated H3K27me3 modification in C2 (Figure 5C). The gene discussed is CRB2; the disease is neoplasm.