Interestingly, although p53 activation is able to modulate the ferroptotic response induced by GPX4 inhibitors, p53-mediated tumor suppression is more closely linked with a distinct ferroptosis pathway upon high levels of reactive oxygen species (ROS) in the absence of common ferroptosis inducers (Jiang et al., 2015; Liu and Gu, 2022). This evidence concerns the gene TP53 and neoplasm.