TP53 and neoplasm: Indeed, the lipoxygenase ALOX12 was identified as a critical factor in ROS-induced ferroptosis during p53-mediated tumor suppression (Chu et al., 2019), and our recent study further showed that PHLDA2 is able to recognize phosphatidic acid and induce its peroxidation by recruiting ALOX12 for tumor suppression (Yang et al., 2024).