Likewise, either loss of PHLDA2 (control A375 vs. PHLDA2–/–) or p53 inactivation (control A375 vs. p53–/–) significantly promoted A375 xenograft tumor growth, while loss of PHLDA2 in p53-null A375 cells failed to further promote tumor growth (p53–/– vs. p53–/–/PHLDA2–/–) (Figure 1I–K). Here, PHLDA2 is linked to neoplasm.