Although the AD-linked APOE jxn1.2.2 mRNA is associated by APOE4 genotype, the association between AD-risk SNPs (e.g., rs157580) we prioritized and jxn1.2.2 expression is independent of APOE4 genotype, indicating an alternative mechanism of APOE mRNA transcription. The gene discussed is APOE; the disease is Alzheimer disease.