To further define the independent effects of our candidate AD alleles on APOE jxn1.2.2 expression from APOE4 and APOE2, we performed epistasis (statistical interaction analysis), and we did not observe significant interactions between our candidate AD alleles and the APOE4/2 risk allele (Supplementary Fig. S6C & S6D), indicating the association between jxn1.2.2 expression and our candidate AD-risk alleles is not influenced by APOE4/2. Here, APOE is linked to Alzheimer disease.