APOE and Alzheimer disease: To determine if the association of AD alleles with jxn1.2.2 transcript is independent of the APOE2,3,4 alleles, we performed the conditional analysis by adding two variables, APOE4 (4 carriers and non-4 carriers) and APOE2 (2 carriers and non-2 carriers), in our regression Model-2 (Supplementary Table S2), and found the significant associations were not influenced compared to original model without APOE4 and APOE2 in 3 independent datasets: ROSMAP, LIBD European and African populations (Supplementary Figs. S6B & S7B & S8B & S10, Table S6 & S7).