APOE and Alzheimer disease: To assess the potential influence of ancestry on the relationship between APOE transcripts and AD alleles, we also conducted an analysis of RNA-seq data from the LIBD African ancestry brain DLPFC collections, and this association persists (Fig. 2D, Supplementary Fig. S8A), suggesting a significant link between APOE jxn1.2.2 transcripts and AD alleles in samples from two different ancestries.