CYP2D6 and Alzheimer disease: Similar to our work in SNX19 [35] and CYP2D6 [34] genes, we demonstrate that a careful analysis of postmortem brain data can identify brain region-specific gene transcription mechanisms associated with AD-risk APOE. Our results prioritize specific domains between exon 1 and exon 2 in the protein that contain the functional domain that might influence AD risk.