APOE and Alzheimer disease: Importantly, we uncover that a particular junction between alternative exon 1 and exon 2 (named jxn1.2.2 and tagging the APOE transcript NM_001302688) is the top hit junction at the APOE locus co-localizing with variants associated with AD-risk (p < 1e-7) (Figs. 1B and 2A, Supplementary Fig. S5 and Table S5).