Immunohistochemical staining was further conducted on the subcutaneous tumor tissues of the aforementioned mice treated with 10 mg/kg MGCD-265, indicating an up-regulation of the protein expression levels of JMJD6, CDC25A, HSP90AA1, SLC7A11, and SLC1A5 compared to the control (Fig. 7D). This evidence concerns the gene HSP90AA1 and neoplasm.