It was observed that the Q values of MGCD-265 in combination with SKLB325, a JMJD6 inhibitor, were all greater than 1.15 for all three types of gallbladder cancer cells (Fig. 7B and C; Fig. S12), suggesting that MGCD-265 in combination with SKLB325 might have a more potent anti-tumor effect. The gene discussed is JMJD6; the disease is neoplasm.