INS and kidney disorder: After searching in PhenoScanner, 22 SNPs were removed from the conservative analysis because they are related to known or likely confounders (kidney diseases, lipid parameters, psychosocial and lifestyle outcomes) for Lp(a) level (Supplementary Table 4, Additional file 2, records with exclusion reasons for SNPs are presented in bold) to remove pleiotropic SNPs that may affect Lp(a) levels through mechanisms other than affecting apo(a) expression via insulin [42].