Serum autoantibodies associated with SRDs are often detected in PBC [9, 15], including rheumatoid factor, anti-CCP, anti-dsDNA, anti-Ro/SSA, etc. Antinuclear antibodies (ANAs) exhibiting the “multiple nuclear dots” or “rim-like immunofluorescence” patterns showed high specificity for PBC and these ANAs were also detected in SRDs [16]. The gene discussed is TRIM21; the disease is primary biliary cholangitis.