We found increased expression of target genes of the JNK, TOLL and UPD3 inflammation-associated pathways in neural tissues of head STZ-injected cockroaches, like records of proinflammatory cytokine response during neurodegeneration in STZ diabetic rats [70], thereby lending credence to remedies that target the mechanisms of redox-inflammatory crosstalk in neurodegenerative diseases for therapeutic advantage. Here, MAPK8 is linked to neurodegenerative disease.