SPRY4 and pulmonary arterial hypertension: The THBS1, COMP, SIGLEC1, and IFI44 are correlated moderately with the mRSS, and further analyses have confirmed that HOTTIP and SPRY4-IT1 show positive correlation with mRSS; otherwise, ANCR and SPRY4-IT1 are significant biomarkers for PAH [142].