The pathogenic association in Ssc could be grouped in three major pathways, such as genes, associated with vascularization (eNOS, ACA, ET-1, ETR-A/B), immune or inflammatory genes (STAT4, IRF5, CD247), and genes associated with fibrotic processes (MIF, CTGF, Fibrillin-1, SPARC) [5]. Here, EDN1 is linked to systemic sclerosis.