Consistently, Chae et al. [44] reported that Hsp90 inhibition following Gamitrinib treatment impacts the expression of mitochondrial transcription factors (i.e. TFB1M and TFB2M) and ribosomal proteins associated with RNA translation (i.e. MRPLs, MTG1 and ERAL1) in glioblastoma cells, suggesting that the Hsp90-directed protein folding in mitochondria controls central metabolic networks in tumour cells [44]. The gene discussed is TFB2M; the disease is glioblastoma.