PPARGC1A and colorectal carcinoma: Thus, according to previous studies showing the inverse correlation between p-ERK1/2 and PGC1-α levels in different pathophysiological conditions [29], it is intriguing to hypothesize that ERK signalling modulation may occur downstream to TRAP1 protein network and upstream to PGC-1α/TFAM signalling, representing a regulatory axis of MB in human CRC cells.