JUN and cancer: Numerous ChIP-Seq studies in cancer cells have documented a substantial overlap of YAP/TAZ, TEAD, and AP-1 binding in the genome (Stein et al, 2015; Zanconato et al, 2015), and JUN/FOS AP-1 complexes are required for full transcriptional activity of YAP/TAZ (Shao et al, 2014).