GNPAT and neutropenia: However, since neutropenia was not observed in other mouse models of ether lipid deficiency, such as GNPAT knockout mice, or in patients suffering from RCDP, it was argued that accumulation of the intermediate 1-O-alkyl-glycerone phosphate or tamoxifen toxicity might be responsible for neutrophil death observed in PexRAP-deficient mice [26].