Bithionol reduced the protein expression of elements of the NF-κB p65 signalling pathway, as well as the phosphorylation of key elements of this pathway, causing a decrease in the nuclear translocation of NF-κB p65, indicating that bithionol can suppress NF-κB p65 signalling in AML cells. The gene discussed is RELA; the disease is acute myeloid leukemia.