IFNG and melanoma: Indeed, IFN-γ producing γδ T cells display potent cytotoxic effects, leading to delayed tumor growth in the murine B16 melanoma and chemical carcinogen methylcholanthrene models.39 40 In humans, recent studies have connected Vδ1-expressing γδ T cells with protective immunity.41 42 Intriguingly, antitumor functions in murine γδ T cells were most closely mirrored by Vγ1+ and Vγ7+ cells.42