The success of such therapies would be reflected by an altered quantity and quality of the tumor immune infiltrate, whereby enhanced infiltrates of cytotoxic lymphocytes such as CD8+ T cells, NK cells and γδ T cells are associated with a favorable prognosis.31 32 Of the immunotherapeutic options explored in clinical studies, immune checkpoint inhibitors have shown remarkable efficacy.33 This evidence concerns the gene CD8A and neoplasm.