Several inflammatory diseases are associated with CNO, including inflammatory bowel disease (IBD), in approximately 10% of CNO patients,5,19,20 cutaneous manifestations (18%–21%,5,21,22), including psoriasis which may be more prevalent in patients treated with TNF inhibitors (TNFi),5,23 severe acne, Sweet syndrome and pyoderma gangrenosum, and Takayasu arteritis.24–27. The gene discussed is TNF; the disease is inflammatory bowel disease.