Antiphospholipid antibodies, such as aCL, aβ2-GP, and lupus anticoagulant, belong to a heterogeneous group of antibodies associated with Antiphospholipid Antibodies Syndrome (APS), a thrombosis-related systemic autoimmune disease affecting arteries, veins, and small blood vessels.25 Here, ACLY is linked to autoimmune polyendocrinopathy.