Another two samples presented four cancer drivers, consisting of TP53 in concomitance with three TSG (ATXN1, PTPN13, and BRCA1) in one of the tumors, and two TSGs (NF1 and FBXW7) in association with two oncogenes (PIK3CA and FBXW7) in the other tumor. The gene discussed is PIK3CA; the disease is cancer.