ESR1 and obesity due to melanocortin 4 receptor deficiency: Based on the pathway from BioPlanet, the three targets were found to be involved in the PPAR-gamma coactivator role in obesity and thermogenesis; energy metabolism; transcriptional regulation of white adipocyte differentiation; lipid metabolism regulation by peroxisome proliferator-activated receptor alpha (PPAR-alpha); fatty acid, triacylglycerol, and ketone body metabolism; Huntington’s disease; CARM1 and regulation of the estrogen receptor; RORA activation of circadian expression; and developmental biology.