Enrichment analysis revealed that the frequently altered genes were involved in complex pathways in cancer (e.g., TP53, RTK/RAS and PI3K pathway), biological processes (e.g., replicative senescence and positive regulation of pri−miRNA transcription), cellular components (e.g., ML body and chromosome/telomeric region), and molecular functions (e.g., ATP binding and enzyme binding). The gene discussed is TP53; the disease is cancer.