MSH2 and neoplasm: In addition, according to potential driver genes in five data sources, we identified seven oncogenes or tumor-suppressor genes, including EGFR (7p11.2, 25.49%), PTEN (10q23.31, 21.57%), MLH1 (3p22.2, 19.61%), ATR (3q23, 11.76%), FGFR2 (10q26.13, 11.76%), MSH2 (2p21, 11.76%), and MUC16 (19p13.2, 9.50%) (S2 Table and Fig 3C).