Despite the high burden of malaria in this study, only 4 of 2,266 episodes (0.2%) met WHO criteria for severe malaria: 2 cases of severe anemia (Hb < 5.0 gm/dL) occurred in children with confirmed sickle cell disease, one of whom died; 1 case of severe anemia occurred in a 1 year old child who recovered; and 1 case of jaundice occurred in a 3 year old child who recovered. The gene discussed is GSTM1; the disease is sickle cell disease.