The ESR1-DAB2 cistromic-transcriptomic overlap revealed enrichment of RCAN1, which has an isoform (RCAN1.4) that has been associated with tumor suppression in one study, as well as an upstream negative regulator of Myc-1, FILNC1 (Fig. 5C) (53, 54). Here, RCAN1 is linked to neoplasm.