Diverse therapeutic approaches are effective in Tg26 kidney disease, including inhibitors of mammalian target of rapamycin (Kumar et al., 2010; Yadav et al., 2012; Rai et al., 2013), Notch inhibition (Sharma et al., 2013; Puri et al., 2019), renin-angiotensin system inhibition (Zhong et al., 2013; Rai et al., 2014), cyclin-dependent kinase inhibition (Gherardi et al., 2004), sirtuin1 agonist or overexpression (Wang et al., 2020), STAT3 activation reduction (Feng et al., 2009; Gu et al., 2013), retinoic acid receptor agonist (Ratnam et al., 2011), and NF-kB inhibition (Zhang et al., 2012). This evidence concerns the gene STAT3 and kidney disorder.