Interestingly, and in contrast with total IgG response levels (Figure 2C), which exhibited statistically significant but relatively small differences in response magnitude, FcγR-binding antibodies were both significantly and strongly elevated among participants with chronic CMV infection (Figure 2B and Supplemental Figure 5), suggesting the presence of qualitative differences in the antibodies present during primary and chronic infection that may affect the effector functions mediated by this class of widely expressed innate immune cell receptors. The gene discussed is FCGR2A; the disease is cytomegalovirus infection.