IDH3A and neoplasm: To determine whether patient BVax-derived, Ig-recognized antigens are accessible to the immune system, we performed intraoperative high-molecular-weight microdialysis, which collects proteins secreted into the interstitial fluid space (40), in the tumor and brain tissue adjacent to the tumors of patients with GBM (GBMWT3, and GBMWT4) and in 1 patient with a grade 4 isocitrate dehydrogenase–mutant (IDH-mutant) astrocytoma (Astro4-mut3), followed by MS analysis (Figure 6A).