In this setting, patients with AR-high tumors had worse outcomes when considering all prostate tumor biopsies (HR = 2.0, 95% CI = 1.7–2.3, P value < 0.0001) or bone (HR = 2.6, 95% CI = 1.8–3.6, P value < 0.0001) and lymph node metastasis (HR = 2.1, 95% CI = 1.6–2.7, P value < 0.0001). The gene discussed is AR; the disease is prostate neoplasm.