Deploying the novel ALAN computational approach captured 6 APUC genes (HSD3B1, HSD3B2, CYP11A1, CYP11B1, CYP3A43, and CYP171A1) that, when analyzed collectively, exhibited consistent and robust associations with outcome in prostate biopsies or metastatic PC. This evidence concerns the gene CYP3A43 and pachyonychia congenita.