HSD3B1 and pachyonychia congenita: Deploying the novel ALAN computational approach captured 6 APUC genes (HSD3B1, HSD3B2, CYP11A1, CYP11B1, CYP3A43, and CYP171A1) that, when analyzed collectively, exhibited consistent and robust associations with outcome in prostate biopsies or metastatic PC.