Of the many APUC genes that have been associated with the activation of AR, we found that 6 (HSD3B1, HSD3B2, CYP11A1, CYP11B1, CYP17A1, and CYP3A43) exhibit robust association in prostate and metastatic tumors and were mutually exclusive with heightened AR activity. Here, CYP3A43 is linked to metastatic neoplasm.