AR and pachyonychia congenita: Unsupervised clustering of prostate tumor biopsies (Caris, n = 4,490) and metastatic PC biopsies (Caris, n = 2,593) indicated that the expression of the 6 APUC genes was again clustered as evident by the origin at the same branch point, but interestingly not with AR, as it is the furthest branch point from APUC genes (Figure 1D).