Unsupervised clustering of ALAN outputs indicated that 6 out of 21 APUC genes, HSD3B1, HSD3B2, CYP11A1, CYP11B1, CYP17A1, and CYP3A43, exhibited increasing association with respect to disease progression from benign to primary PC, but only exhibited robust association in metastatic PC, indicating context-specific coalescent behavior (Figure 1B). This evidence concerns the gene HSD3B1 and pachyonychia congenita.