IFN-γ is a major mediator of immune-mediated bone marrow failure both in the setting of acquired aplastic anemia (41, 52–54) and in cytopenia developing after chimeric antigen receptor T cell therapy (55), and an interferon signature has already been reported in allogeneic transplant recipients by Montaldo et al. (26). This evidence concerns the gene IFNG and Bone marrow hypocellularity.