PRDM16 and Alzheimer disease: By combining single nucleus RNA sequencing (snucRNAseq) of the human brain with additional transcriptome data from human tissues we identify PRDM16-DT as the most highly enriched lncRNA in astrocytes with a murine homolog named Prdm16os. PRDM16-DT is downregulated in reactive astrocytes and in the brains of individuals with AD.