FUS and amyotrophic lateral sclerosis: However, in about 5–10% of cases, ALS is familial (fALS), with around 70% of these cases linked to genetic mutations in the Superoxide dismutase 1 (SOD1) gene, Chromosome 9 open reading frame 72 (C9orf72) gene, Trans-activation response (TAR) DNA-binding protein 43 (TARDBP) gene, and Fused in sarcoma (FUS) gene [3].