THBS1 and digestive system neoplasm: Both collagen type III and thrombospondin 1 expressed in high amounts in adipose tissue have been linked to insulin resistance in fat cells, which may further exacerbate the development of fatty liver (Contreras et al., 2018; De Koster & Opsomer, 2013; De Smet et al., 2004; Locher et al., 2011; Tchkonia et al., 2013).