CRLS1 and non-small cell lung carcinoma: For example, cardiolipin is synthesized by cardiolipin synthase 1 (CRLS1), and an abnormally high expression of CRLS1 has been shown to be associated with improved survival of patients with non-small cell lung cancer and lung adenocarcinoma, highlighting a potential link between the regulation of mitochondrial lipids and tumor suppression (59).