Obesity induced by a high‐fat diet increases PA levels, which can upregulate the expression of intracellular TLR2 and TLR4, generate reactive oxygen species (ROS), increase NF‐κB activity, induce the expression and activity of Toll‐like receptors (TLR), and release inflammatory factors (Dasu & Jialal, 2011; Qiu et al., 2022). The gene discussed is TLR4; the disease is obesity due to melanocortin 4 receptor deficiency.