Our Salmonella data include data from the CVD908-htrA vaccine derivative of Salmonella enterica serovar Typhi Ty2 (25), the common S. Typhimurium lab strain SL1344 and its vaccine derivative SL3261 (18), the S. Enteritidis PT4 strain P125109 (34) representative of the global gastroenteritis epidemic, and S. Typhimurium D23580 (35) and A130, representatives of the two major clades involved in the HIV-associated invasive non-typhoidal salmonellosis epidemic in sub-Saharan Africa (36). The gene discussed is HTRA1; the disease is gastroenteritis.