SPP1 and chordoma: It has been reported that SPP1+ TAMs exhibit immunosuppressive characteristics, indicating poor prognosis in various types of cancer.[25, 26] Furthermore, previous observations have confirmed that chordomas have an inhibitory immune microenvironment, where the density of immune cells significantly affects disease progression.[8, 27, 28] Taking together, we speculate that GMFG may potentially mediate biological functions through activating the SPP1/ITGB1 pathway to induce immunosuppression in the microenvironment.