Previous reports have suggested that GMFG can enhance invasion and metastasis of tumor cells by regulating the stability of ITGB1 molecule to induce migration of myeloid‐derived suppressor cells into the tumor microenvironment.[44] Additionally, both GMFG and ITGB1 expressions are reported to correlate with the densities of microenvironmental immune cells.[45, 46] Our subsequent analyses hinted at a spatial relationship between ITGB1+ tumor cells and SPP1+ TAMs, which were both related to clinical data of patients. This evidence concerns the gene ITGB1 and neoplasm.