CFL1 and breast cancer: As a vital ADF/cofilin protein superfamily member, GMFG is key regulator of actin cytoskeleton reorganization.[38] Researchers have found that GMFG is of significance in angiogenesis and knockdown of this gene can severely hinder intersegmental vessel formation in zebrafish.[39] In the cancer realm, it has been reported that GMFG functions as a critical oncogene in mediating proliferation and invasion of ovarian and breast cancer cells.