Interestingly, a previous report suggested that CERS6, a rate limiting sphingolipid for the de novo ceramide biosynthesis enzyme, is expressed predominantly in the perinuclear region and regulates the nuclear translocation of active caspase‐3 involved in the control of cell apoptosis.[44] It is also known that cancer cells tightly regulate ceramide signaling.[45] Notably, as a mechanism for aberrant growth, cancer cells upregulate enzymes that metabolize ceramides because these lipids can cause cancer cell programmed cell death. This evidence concerns the gene CERS6 and cancer.