Reflecting its central role in de novo dNTP biosynthesis, high expression of the small RNR subunit RRM2 has been reported in a variety of cancer types and correlates with worse prognosis (Liu et al., 2013, 2012; Morikawa et al., 2010a,b; Wang et al., 2012; Zhou et al., 2022). This evidence concerns the gene NR2E3 and cancer.