ACSs include short‐chain ACSs (ACSS), medium‐chain ACSs (ACSM), long‐chain ACSs (ACSL), and very long‐chain ACSs (ACSVL), named after the carbon chain length of their respective substrate,[22] among which the ACSL family stands out for its involvement in multiple metabolic fates and their various intricate relationships with cancer.[23, 24] Compared with other isoenzymes (ACSL1 and ACSL3–5), the role of ACSL6 in cancer has not been fully investigated.[24]. The gene discussed is ACSL3; the disease is cancer.