MAPT and tauopathy: In tauopathies, axonal loss may be ascribed to tau‐related or microtubule depolymerization protein‐mediated mechanisms.[19] Kif2a, a member of the kinesin‐13 family, promotes microtubule disassembly, and hence, its hyperactivation could account for microtubule loss.[20] In differentiated neurons, Kif2a mediates axonal degeneration by regulating microtubule disassembly and axonal breakdown during axonal pruning.[21] In proliferating cells, Kif2a is distributed in the nucleus and cytoplasm during interphase, while aggregates of spindle microtubules and poles initiate prophase.