Loss of Smek1 in C. elegans resulted in shortened life expectancy.[9] Recent results indicated that Smek1 mediates stress resistance and longevity in C. elegans by regulating the transcriptional initiation of DAF‐16‐activated genes.[10] In the current study, we address the role of Smek1 in triggering tauopathy and neurodegeneration. This evidence concerns the gene PPP4R3A and tauopathy.