demonstrated a novel genome‐wide significant association between rs2273647‐T in SMEK1 and cognitive decline in AD and mild cognitive impairment.[6] They also conducted a follow‐up study and found a distinct variant in SMEK1 associated with the risk of AD, which further confirmed the role of SMEK1 in disease progression. The gene discussed is PPP4R3A; the disease is Cognitive impairment.