Consistently, IHC assays showed that TBC1D31 protein levels are significantly positively correlated with the levels of EGFR, p‐EGFR, p‐ERK1/2 and p‐AKT in subcutaneous tumor tissues from nude mice (Figure S5e, Supporting Information), and the HCC tissues from the VALI cohort (n = 168; Figure 3e). Here, MAPK3 is linked to hepatocellular carcinoma.