EGFR and hepatocellular carcinoma: Emerging evidence has shown that the defective endocytic trafficking of EGFR by a group of Rab GTPases has been recognized as a novel mechanism for regulating the expression and activity of EGFR.[14, 15, 16, 17] However, multiple facets of the EGFR trafficking mechanism in HCC cells are still far from being elucidated.