Mechanistically, TBC1D31 delays EGFR degradation through hydrolyzing Rab22A, which has been shown to act as a promoter in the trafficking of EGFR from early endosomes to late endosome/lysosomes for degradation, thereby enhancing the EGFR signaling in HCC cells. The gene discussed is TBC1D31; the disease is hepatocellular carcinoma.