TBC1D31 and hepatocellular carcinoma: Notably, 8q24 amplification is one of the most common genomic alterations in HCC, and is associated with HCC progression due to its ability to drive the oncogene MYC on 8q24.21.[31] Thus, our findings highlight the biological relevance of the newly identified 8q24.13 amplification and its critical gene TBC1D31 to the development of HCC in the context of broader chromosome 8q gain.