Notably, 8q24 amplification is one of the most common genomic alterations in HCC, and is associated with HCC progression due to its ability to drive the oncogene MYC on 8q24.21.[31] Thus, our findings highlight the biological relevance of the newly identified 8q24.13 amplification and its critical gene TBC1D31 to the development of HCC in the context of broader chromosome 8q gain. The gene discussed is MYC; the disease is hepatocellular carcinoma.