EGFR and cancer: Epidermal growth factor receptor (EGFR) is a member of the receptor tyrosine kinases (RTKs) family and plays critical roles in the malignant transformation and metastasis of cancers.[11] Numerous genomic studies have shown that EGFR is recurrently disrupted by genomic alterations in various types of cancer.[12] With regard to HCC, less than 5% of patients have oncogenic mutations or amplifications in EGFR.