NRF1 and atherosclerosis: NRF1 (Nuclear respiratory factor 1) is a transcription factor closely related to modulation of key metabolic genes for cell growth and development.[47] One recent study showed that NRF1 attenuated the development of atherosclerosis via suppressing the proliferation and migration of vascular SMC,[48] indicating a protective role of NRF1 in regulating vascular remodeling.