LIF and cancer: The tumor microenvironment (TME) dictates CSC maintenance to orchestrate cancer initiation and progression through intricate crosstalk between CAFs/immune cells and cancer cells.[44] Prior studies have provided clues that CAFs secreted LIF to promote malignant phenotypes of oral SCC.[30, 45] Results retrieved from TIMER2.0 indicated a strong positive correlation between LIF transcripts and CAFs infiltrations in TCGA‐PanCancer datasets (Figure S23, Supporting Information).