STAT3 and head and neck squamous cell carcinoma: Previous reports have established SOX2 as a key lineage‐specific CSCs regulator in HNSCC.[42, 48] In line with this, our results from ATAC‐seq, ChIP‐seq, and ChIP‐qPCR assays confirmed that STAT3 binding at the SOX2 promoter activated its transcription, which in turn governed HNSCC stemness.