LIF and esophageal adenocarcinoma: Although similar LIF‐SEs have been identified as pivotal oncogenic SEs in osteosarcoma and esophageal adenocarcinoma, their biological roles and detailed mechanisms of action are still underexplored.[26, 37] We exploited the ABC model, HiChIP data analysis, and chemical intervention assays to establish that LIF was the primary transcriptional target of LIF‐SE rather than those genes in proximity in HNSCC.