Interestingly, this LIF‐SE region has been identified as an oncogenic SE in multiple cancers such as osteosarcoma and esophageal adenocarcinoma.[26, 37] Collectively, our findings characterized the aberrant SE landscape in HNSCC and underscored LIF‐SE as a representative GAIN‐SE in HNSCC for further experimental explorations. This evidence concerns the gene LIF and osteosarcoma.