Previous reports have established SOX2 as a key lineage‐specific CSCs regulator in HNSCC.[42, 48] In line with this, our results from ATAC‐seq, ChIP‐seq, and ChIP‐qPCR assays confirmed that STAT3 binding at the SOX2 promoter activated its transcription, which in turn governed HNSCC stemness. The gene discussed is SOX2; the disease is head and neck squamous cell carcinoma.