To substantiate the presence of LIF‐SE in HNSCC clinical samples, we performed H3K27ac ChIP‐seq in freshly collected HNSCC (HNSCC1 and HNSCC2) and normal oral mucosa (NOM) samples and identified similar LIF‐SE loci in primary cancer samples only (Figure 2K; Figure S7, Supporting Information). Here, LIF is linked to head and neck squamous cell carcinoma.