To further consolidate the LIF‐SE status, we assembled multiple ChIP‐seq datasets and found significant binding enrichments of H3K27ac, H3K4me1, BRD4, MED1, and EP300, but reduced binding of H3K27me3 and H3K36me2 in LIF‐SE across multiple HNSCC cells (Figures 2K and 3A; Figure S8, Supporting Information). Here, BRD4 is linked to head and neck squamous cell carcinoma.