Next, we sought to determine the potential target genes modulated by LIF‐SE by utilizing the activity‐by‐contact (ABC) model.[38] Six potential LIF‐SE‐contact genes (LIF, CASTOR, CCDC157, TBC1D10A, SF3A1, and RNF215) were predicted and LIF was the top one with the highest scores among all LIF‐SE enhancer fragments across four HNSCC cell lines (Figure 3B; Figure S10, Supporting Information). The gene discussed is RNF215; the disease is head and neck squamous cell carcinoma.