Next, we sought to determine the potential target genes modulated by LIF‐SE by utilizing the activity‐by‐contact (ABC) model.[38] Six potential LIF‐SE‐contact genes (LIF, CASTOR, CCDC157, TBC1D10A, SF3A1, and RNF215) were predicted and LIF was the top one with the highest scores among all LIF‐SE enhancer fragments across four HNSCC cell lines (Figure 3B; Figure S10, Supporting Information). This evidence concerns the gene SF3A1 and head and neck squamous cell carcinoma.