Recent studies have highlighted the role of FOXO1 in ferroptosis, demonstrating its inhibitory effect on GPX4, which not only prevents prostate cancer metastasis but also induces ferroptosis in cervical cancer cells.[36, 37] Additionally, FOXO1‐induced upregulation of FTH1 has been shown to inhibit ferroptosis in cardiomyocytes.[38] Our findings align with these reports, indicating FOXO1's involvement in inhibiting ferroptosis and revealing a novel mechanism by which FOXO1 counteracts NCOA4‐mediated ferritinophagy and subsequent ferroptosis. This evidence concerns the gene NCOA4 and Familial prostate cancer.