ACSL4 and diabetes mellitus: However, evidence from another study suggested that FOXO1 promotes ferroptosis in pancreatic β cells in type 2 diabetes mellitus, where FOXO1 knockdown reduced ROS, iron, and ACSL4 levels while increasing GPX4 levels.[64] This suggests the complex and context‐dependent relationship between FOXO1 and ferroptosis, likely influenced by the specific downstream targets regulated by FOXO1.