SLC2A1 and Hyperglycemia: Regarding glucose transporters, we observed the up-regulation of solute carrier family 2 member a 1 (Slc2a1; Glut1) accompanied by concomitant down-regulation of Slc2a4 (Glut4) in FH hearts supporting insulin resistance and increased unregulated glucose uptake in the face of permanent hyperglycaemia in the remodelled myocardium of FH.