Some studies suggest that silicosis is caused by oxidative stress induced by silica, while others propose that it is due to the release of various bioactive substances such as TNF‐α and TGF‐β triggered by free radical chain reactions.[22] Whether inflammatory granuloma or foreign body granuloma, the persistence will develop into tissue organization characterized by an increase in collagen fibers, with fibroblasts gradually decreasing and transforming into a quiescent state, and eventually into fibrotic tissue. This evidence concerns the gene TNF and silicosis.