NOTCH1 and pancreatic neoplasm: Notch1 signaling pathways induce promoter activity and expression of multiple NF-κB subunits, as shown in mice in which decreased NF-κB activity leads to downregulation of Notch signaling pathways.74 Wang et al. investigated the effect of curcumin on the Notch1 signaling pathway in pancreatic cancer (BxPC-3 and PANC-1 cells).