NOTCH1 and cancer: They also found that treatment of pancreatic cancer cells with miR-34a and genistein significantly reduced Notch1 levels compared to genistein alone.91 Zhou et al reported that genistein decreased the expression of Notch1 signaling protein and also induced the expression of Bax/Bcl-2, caspase-8 and caspase-3 in HT-29 cells (colon cancer), which decreased cancer cell growth and increased apoptosis.92 Some studies have shown that genistein suppresses the activity of Akt, leading to inactivation of the downstream signaling pathways, NF-κB.