In vitro studies have shown that genistein inhibits EGF receptor activity by interacting with tyrosine–specific protein kinase-like EGF receptor and histone H2B as a phosphate receptor.88,89 MiR-34a is a miRNA involved in the suppression of cell growth by inhibiting Notch1 expression in pancreatic cancer.90 Xia et al revealed that treatment of pancreatic cancer cells with genistein resulted in increased re-expression of miR-34a in cancer cells and down-regulation of Notch1. Here, NOTCH1 is linked to familial pancreatic carcinoma.