STAT3 and osteosarcoma: Downregulation of DLL4 leads to decreased expression of EphrinB2 and HEY1 and prevents proliferation, migration, and network formation of endothelial cells, all of which play important roles in tumor angiogenesis.124 The study on human osteosarcoma cells treated with resveratrol showed it led to the inhibition of JAK2/STAT3 signaling reduced cell viability, self-renewal ability, and tumorigenesis.