This result proves the interaction between Notch1 and the NF-κB signaling pathway.72 Studies in oral cancer cells have shown that curcumin reduces Notch1 activity, leading to downregulation of NF-κB and its target genes such as Bcl-2, cyclin D1, VEGF, and MMP-9.71 The expression of HES1 proteins, which are the target genes of Notch1 and influence cell fate, was also decreased.75 Since curcumin has photodynamic properties, a combination of photodynamic therapy (PDT) and Notch receptor blockers (DAPT) was used. Here, NOTCH1 is linked to lip and oral cavity carcinoma.